Poor Air Quality Links with Gene Dysregulation Causing Cancer

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Delhi BJP protests against pollution Image credit The Raisina Hills

Delhi BJP protests against pollution Image credit The Raisina Hills

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Air Pollution Leads to liver inflammation, fibrosis, blood fat imbalance, liver protein markers

By Bryan Johnson

Indians are justifiably outraged by the poor air quality they are exposed to daily. It creates serious negative health effects.

Below is a study showing how air pollution causes liver inflammation, fibrosis, blood fat imbalance, and liver protein markers associated with alcoholism, as well as gene dysregulation linked to cancer.

There’s no such thing as safe level of PM2.5.

Study results: Mice exposed to 12-weeks of low levels of traffic PM2.5 pollutants developed liver inflammation, fibrosis, blood fat imbalance, and exhibited liver protein markers associated with alcoholism and gene dysregulation related to cancer.

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Background: Air pollution is multifaceted, with small particulate matter PM2.5 that can reach deep into the lungs and cross to circulation being the most notorious “everyday” air pollutant linked to traffic and combustion engines.

Method: The study mimicked the prolonged exposure to everyday “low-level” traffic pollution by collecting the particulate matter PM2.5 from the side of busy roads and introduced the pollutants in a saline solution into the mice noses.

Negative controls received a pollutant-free solution.

Conclusion and significance: The study is a stark reminder that there is no safe-level exposure to air pollution, emphasizing the need to treat this as a public health priority.

Especially in heavily polluted cities and countries (for example solving air pollution in India would add more average life expectancy than treating all cancers there).

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Moreover, the study shows mechanistic evidence of air pollution causing systemic damage beyond the lungs and respiratory system.

To minimize your personal exposure 1. Be aware of PM2.5 levels via IQ Air website or an air quality monitor you have with you 2. Wear an N95 mask when in polluted environments 3. Upgrade your home HVAC system to MERV 13 or higher 4. Activate air recirculation in your car when travelling through busy and polluted roads.

Keep in mind that full air recirculation should only be used for a few minutes, as longer use can increase CO2 concentrations, possibly affecting alertness and focus while driving.

  1. Check if your car has a partial recirculation mode, these help keep PM2.5 at lower levels while maintaining a low CO2 concentration too.
  2. Use in-home HEPA filters if you live in an area of high traffic, or high air pollution due to other reason like e.g. wild fires.

(Bryan Johnson posted the above findings of the study on X)

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